A dentist named Parkhouse (Lynne Overman) plays a practical joke on a poker-playing buddy by sending him home with a lady's chemise stuffed in his coat pocket. The gag backfires, whereupon Parkhouse finds himself in hot water with his own wife (Spring Byington). Threatened with divorce, Parkhouse is advised by a zany astrologer to frame Mrs. P. in a compromising situation at the Hotel Haywire, enlisting amateur detectives Bert and Genevieve Sterns (Baker and Lyons) in his scheme.